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KMID : 0384620110220040172
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Korean Journal of Medical Physics
2011 Volume.22 No. 4 p.172 ~ p.177
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Small Animal PET Imaging Study of 68Ga-BAPEN
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Kim Ji-Who
Lee Jae-Sung
Yang Bo-Yeun
Kim Su-Jin
Kim Joong-Hyun
Jeong Jae-Min
Lee Dong-Soo
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Abstract
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The purpose of this study was to analyze ??Ga-BAPEN dynamic PET image in rat myocardium to evaluate potential of this radiotracer as a perfusion imaging agent. Animal PET/CT scan was done in 9 rats during 120 minutes. Especially we synthesized ??Ga-BAPEN with kit which is simple and low cost method. PET images showed the in vivo dynamic distribution of ??Ga-BAPEN in the chest region of rats. Initially ??Ga-BAPEN PET images showed aorta and liver activities and a few minutes later, ??Ga-BAPEN moved to myocardium. Regions of interest were drawn on myocardium, liver, lung and blood pool. Time-activity curves showed significant uptake of ??Ga-BAPEN in myocardium. The contrast ratios of myocardial to blood pool, lung and liver at 60 minutes after injection were 1.66, 2.82 and 0.60. To estimate accurate kinetic parameters, 60 minutes after injection was required to PET scan as myocardium image contrast ratios reached to constant values. As a result, ??Ga-BAPEN would be suitable radiotracer for PET which can applied to diagnosis of myocardial perfusion diseases after further preclinical and clinical investigations.
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KEYWORD
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-??GaBAPEN, Myocardium, PET, Rat
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